Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 12/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | FABP2 | P12104 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8501617 | 0.89 | AKR1C3 (0.58) | AKR1C3AKR1C2PDGFRBPDGFRAPTGS1 | |
| SCHEMBL8889529 | 0.85 | FFAR1 (0.48) | AKR1C3AKR1C2PDGFRBPDGFRAMAP4K4 | |
| SCHEMBL8889522 | 0.80 | PDGFRB (0.47) | AKR1C3AKR1C2PDGFRBPDGFRAMAP4K4 | |
| Fluprofen SCHEMBL29357121 | 0.79 | PTGS2 (0.69) | AKR1C3AKR1C2PTGS1PTGS2MEN1 | |
| Fluprofen SCHEMBL416261 | 0.79 | PTGS2 (0.69) | AKR1C3AKR1C2PTGS1PTGS2MEN1 | |
| SCHEMBL8499693 | 0.78 | PDGFRB (0.52) | PDGFRBPDGFRAHPGDMAP4K4CSNK1G2 | |
| SCHEMBL8887119 | 0.78 | PDGFRB (0.47) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8889438 | 0.77 | PDGFRB (0.55) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8502976 | 0.77 | AKR1C3 (0.44) | AKR1C3AKR1C2PDGFRBPDGFRAPTGS2 | |
| SCHEMBL8890269 | 0.75 | FFAR1 (0.48) | AKR1C3AKR1C2PDGFRBPDGFRAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |