SCHEMBL850128

SCHEMBL850128

CC(=O)NC(Cc1cn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.62
PTGS2 P35354 3/20 0.62
HTR6 P50406 8/20 0.56
L3MBTL1 Q9Y468 1/20 0.54
ALK Q9UM73 1/20 0.53
CYP19A1 P11511 1/20 0.50
KDM4E B2RXH2 1/20 0.49
UBE2N P61088 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14286783 0.89 ALOX5 (0.55) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL838015 0.83 HTR6 (0.64) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL838017 0.83 HTR6 (0.64) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL26193435 0.80 HTR6 (0.50) ALOX5PTGS2HTR6
SCHEMBL9054387 0.79 HTR6 (0.67) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL29169606 0.78 HTR6 (0.67) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL946516 0.78 HTR6 (0.74) ALOX5PTGS2HTR6L3MBTL1ALK
SCHEMBL24719041 0.77 ADAM17 (0.53) KDM4E
SCHEMBL22521341 0.77 ADAM17 (0.53) KDM4E
SCHEMBL27153025 0.77 ADAM17 (0.53) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9109048-B2 Inhibition of tumor growth LYTIX BIOPHARMA AS (NO) 2015-08-18 US disclosed
US-20140037657-A1 INHIBITION OF TUMOR GROWTH LYTIX BIOPHARMA AS (NO) 2014-02-06 US disclosed
US-8283315-B2 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2012-10-09 US disclosed
US-8143211-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2012-03-27 US disclosed
US-20080287346-A1 Bioactive peptides SVENDSEN JOHN SIGURD 2008-11-20 US disclosed
US-7439228-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2008-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287346-A1 Bioactive peptides VIP, NGLY1, IAPP ALOX5 1789/4885PTGS2 4220/4885HTR6 4337/4885
US-20140037657-A1 INHIBITION OF TUMOR GROWTH STING1, VIP, MIF ALOX5 285/4885PTGS2 1418/4885HTR6 4531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.