Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500652 | 0.91 | FFAR1 (0.38) | PPARGITGB3ITGA2BLMNAMAPT | |
| SCHEMBL8498404 | 0.88 | PPARG (0.43) | PPARGSENP1LMNAMAPK1SIRT2 | |
| SCHEMBL8526327 | 0.81 | ITGB3 (0.49) | ITGB3ITGA2B | |
| SCHEMBL7856521 | 0.78 | PPARG (0.60) | PPARGITGB3ITGA2BSENP1LMNA | |
| SCHEMBL7450519 | 0.77 | PPARG (0.65) | PPARGITGB3ITGA2BSENP1LMNA | |
| SCHEMBL7856474 | 0.72 | SIRT2 (0.51) | PPARGSENP1LMNAMAPK1SIRT2 | |
| SCHEMBL7347252 | 0.72 | ITGB3 (0.38) | ITGB3ITGA2BROCK2HTT | |
| SCHEMBL7348225 | 0.72 | ITGB3 (0.38) | ITGB3ITGA2BSENP1LMNAROCK2 | |
| SCHEMBL8501354 | 0.71 | SENP1 (0.46) | PPARGITGB3ITGA2BSENP1LMNA | |
| SCHEMBL7379804 | 0.71 | ITGB3 (0.55) | PPARGITGB3ITGA2BSENP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |