Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28221547 | 0.85 | NFE2L2 (0.50) | TDP1L3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL4826210 | 0.84 | PDE4A (0.63) | PDE4A | |
| SCHEMBL5877045 | 0.83 | L3MBTL1 (0.53) | TDP1L3MBTL1MAPTCRHBPCRHR2 | |
| SCHEMBL1515750 | 0.83 | L3MBTL1 (0.53) | TDP1L3MBTL1MAPTCRHBPCRHR2 | |
| SCHEMBL8499958 | 0.81 | ALDH1A1 (0.47) | L3MBTL1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL24065953 | 0.79 | MAPT (0.53) | TDP1L3MBTL1MAPTKDM4EHPGD | |
| SCHEMBL28606777 | 0.79 | L3MBTL1 (0.58) | TDP1L3MBTL1MAPTCRHBPCRHR2 | |
| SCHEMBL28639731 | 0.78 | KDM4E (0.52) | TDP1MAPTKDM4EHPGDKMT2A | |
| SCHEMBL17616789 | 0.78 | L3MBTL1 (0.50) | TDP1L3MBTL1MAPTCRHBPCRHR2 | |
| SCHEMBL8784523 | 0.77 | MAPT (0.69) | TDP1L3MBTL1MAPTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918746-A1 | IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998006692-A1 | NOVEL IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |