Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503115 | 0.83 | CA1 (0.51) | ERN1CA1CA2EGFRSRC | |
| SCHEMBL1642697 | 0.81 | CA1 (0.56) | ERN1CA1CA2EGFRSRC | |
| SCHEMBL11071868 | 0.80 | ERN1 (0.51) | ERN1PTGS2CYP3A4CYP2E1CYP2A6 | |
| SCHEMBL894805 | 0.79 | ERN1 (0.57) | ERN1MKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL5457794 | 0.78 | POLB (0.55) | ERN1MKNK1MKNK2EGFRFGFR1 | |
| SCHEMBL31591514 | 0.77 | POLB (0.50) | MKNK1MKNK2EGFRFGFR1KDR | |
| SCHEMBL1578998 | 0.77 | ERN1 (0.65) | ERN1MKNK1MKNK2EGFRFGFR1 | |
| SCHEMBL7101000 | 0.76 | ERN1 (0.54) | ERN1CYP11B1CYP11B2CYP19A1PTGS2 | |
| SCHEMBL5736902 | 0.76 | ERN1 (0.52) | ERN1CA1CA2CYP3A4CYP2E1 | |
| SCHEMBL6040671 | 0.75 | ERN1 (0.64) | ERN1MKNK1MKNK2EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938494-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1997044350-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |