SCHEMBL11071868

SCHEMBL11071868

Cc1c(C=O)cccc1-c1cccnc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 4/20 0.51
CYP2A6 P11509 6/20 0.46
PARP10 Q53GL7 1/20 0.46
PARP11 Q9NR21 1/20 0.46
CYP3A4 P08684 5/20 0.45
CYP2E1 P05181 3/20 0.45
CYP2C9 P11712 3/20 0.45
CYP2B6 P20813 3/20 0.45
CYP2C19 P33261 3/20 0.45
CYP2D6 P10635 2/20 0.45
PTGS2 P35354 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP1A2 P05177 1/20 0.44
PDCD1 Q15116 1/20 0.42
CD274 Q9NZQ7 1/20 0.42
GPR35 Q9HC97 1/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
KMO O15229 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL894805 0.83 ERN1 (0.57) ERN1CYP2A6CYP3A4CYP2E1CYP2C9
SCHEMBL18367731 0.81 ERN1 (0.41) ERN1PARP10PARP11ALDH1A1PDCD1
SCHEMBL8501853 0.80 ERN1 (0.54) ERN1CYP2A6CYP3A4CYP2E1CYP2C9
SCHEMBL7101000 0.80 ERN1 (0.54) ERN1CYP2A6CYP3A4CYP2E1CYP2C9
SCHEMBL4698367 0.79 PDCD1 (0.48) ALDH1A1PDCD1CD274
SCHEMBL31499183 0.79 PDCD1 (0.48) ALDH1A1PDCD1CD274
SCHEMBL30302117 0.78 ERN1 (0.59) ERN1CYP2A6CYP3A4CYP2E1CYP2C9
SCHEMBL21742825 0.78 PTGS2 (0.54) CYP2A6PARP10PARP11CYP3A4CYP2E1
SCHEMBL18378751 0.78 CYP2A6 (0.56) CYP2A6PARP10PARP11CYP3A4CYP2E1
SCHEMBL30395616 0.76 ALDH1A1 (0.52) ERN1CYP2A6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4426524-A Heterocyclic substituted benzyl alcohol, insecticidal ester derivatives, and intermediates FMC CORPORATION (US) 1984-01-17 US disclosed