Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8503920 | 0.98 | NPSR1 (0.56) | NPSR1P2RX1LMNAPTGS1CES2 | |
| SCHEMBL8503876 | 0.93 | NPSR1 (0.55) | NPSR1P2RX1LMNAPTGS1CES2 | |
| Hydrochloric Acid SCHEMBL8705244 | 0.90 | KIF11 (0.52) | NPSR1P2RX1LMNAPTGS1CES2 | |
| SCHEMBL9593411 | 0.87 | P2RX1 (0.65) | NPSR1P2RX1LMNAPTGS1CES2 | |
| SCHEMBL14045943 | 0.84 | NPSR1 (0.61) | NPSR1P2RX1LMNAPTGS1CES2 | |
| SCHEMBL8767967 | 0.83 | GAA (0.58) | P2RX1LMNACES2GAA | |
| Hydrochloric Acid SCHEMBL8392423 | 0.82 | NPSR1 (0.52) | NPSR1P2RX1LMNAPTGS1CES2 | |
| Hydrochloric Acid SCHEMBL8503520 | 0.82 | GAA (0.57) | P2RX1LMNACES2GAA | |
| SCHEMBL6991713 | 0.82 | LMNA (0.67) | NPSR1P2RX1LMNAPTGS1CES2 | |
| Hydrochloric Acid SCHEMBL8393447 | 0.81 | NPSR1 (0.54) | NPSR1P2RX1LMNAPTGS1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |
| CN-1222510-C | Novel benzoylguanidine salt | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-10-12 | — | — | CN | disclosed |
| CN-1491213-A | Novel benzoylguanidine salt | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-04-21 | — | — | CN | disclosed |
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | disclosed |
| EP-0612723-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | disclosed |