Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26373 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL4106752 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL17511861 | 0.74 | NQO2 (0.41) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL31242880 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL29524245 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL10851 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTNPC1POLBRAB9A | |
| SCHEMBL2386458 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL28383190 | 0.70 | ALDH1A1 (0.75) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL10735436 | 0.69 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTGLAACHE | |
| Ammonia Solution, Strong SCHEMBL27985513 | 0.69 | ALDH1A1 (0.60) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| US-5817674-A | ANTIOTENSIN II RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1998-10-06 | — | — | US | disclosed |
| US-5691347-A | ANGIOTENSIN II INHIBITORS AND VASOCONSTRICTION | ROUSSEL UCLAF (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5684028-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1997-11-04 | — | — | US | disclosed |
| US-5674883-A | ANGIOTENSIN II INHIBITOR | ROUSSEL UCLAF (FR) | 1997-10-07 | — | — | US | disclosed |
| US-5674864-A | ANALGESICS; ENDOPEPTIDASE AND ENKEPHALINASE INHIBITORS; CARDIOTONIC, PSYCHOTROPIC AND HYPERTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1997-10-07 | — | — | US | disclosed |
| US-5650414-A | PYRAZOLOPYRIDINES OR IMIDAZOLOPYRIDINES | ROUSSEL UCLAF (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5599830-A | ANGIOTENSIN INHIBITORS | ROUSSEL UCLAF (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5527919-A | Process for the preparation of 1-[(1,1'-biphenyl]-4-YL]-methyl-1H-imidazole-5-carboxylic acids | ROUSSEL UCLAF (FR) | 1996-06-18 | — | — | US | disclosed |
| US-5493046-A | A 1-((4-PHENYL)PHENYL)-METHYLENE)IMIDAZOLE | ROUSSEL-UCLAF (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5470867-A | Imidazoles and their salts having antagonistic activity to angiotesin II recetors | ROUSSEL-UCLAF (FR) | 1995-11-28 | — | — | US | disclosed |
| US-5420138-A | Antivasoconstriction compounds and cardiovascular disorders | ROUSSEL-UCLAF (FR) | 1995-05-30 | — | — | US | disclosed |
| US-5412101-A | Angiotensin II inhibitor | ROUSSEL-UCLAF (FR) | 1995-05-02 | — | — | US | disclosed |
| US-5391732-A | Cardiotonic agents, hypotensive agents, antispasmodic agents | ROUSSEL-UCLAF (FR) | 1995-02-21 | — | — | US | disclosed |
| US-5389634-A | Treating arterial hypertension, relaxing uterus, prevention of post-angioplastic restenosis | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5338756-A | Angiotensin II receptor antagonists | ROUSSEL UCLAF (FR) | 1994-08-16 | — | — | US | disclosed |
| US-5324839-A | Hypotensive agents, gastrointestinal and urogenital disorders | ROUSSEL-UCLAF (FR) | 1994-06-28 | — | — | US | disclosed |
| US-5190974-A | Analgesics | ROUSSEL UCLAF (FR) | 1993-03-02 | — | — | US | disclosed |
| CN-1063869-A | New nitrogenous bicyclic derivatives, its preparation method, the new intermediate that obtains thus, its pharmaceutical use and the pharmaceutical composition that contains this class material | ROUSSEL UCLAF (FR) | 1992-08-26 | — | — | CN | disclosed |
| CN-1057257-A | The new intermediate of new imdazole derivatives and method for making thereof, gained, as the application of medicine with contain their pharmaceutical composition | ROUSSEL UCLAF (FR) | 1991-12-25 | — | — | CN | disclosed |