Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505059 | 0.80 | AGTR2 (0.45) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| SCHEMBL8711112 | 0.77 | AGTR2 (0.44) | AGTR2LTB4R2AGTR1 | |
| SCHEMBL21939312 | 0.75 | ALDH1A1 (0.57) | GUSBALDH1A1PPARG | |
| Azilsartan SCHEMBL167538 | 0.74 | AGTR2 (0.72) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| Azilsartan SCHEMBL29687472 | 0.74 | AGTR2 (0.72) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| SCHEMBL15525727 | 0.74 | AGTR2 (0.50) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| Azilsartan SCHEMBL969381 | 0.73 | AGTR2 (0.71) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| Azilsartan SCHEMBL15552225 | 0.73 | AGTR2 (0.71) | AGTR2LTB4R2AGTR1ABCB11EGFR | |
| SCHEMBL7425056 | 0.71 | DHODH (0.49) | ALDH1A1CYP3A4 | |
| SCHEMBL6111486 | 0.71 | AGTR2 (0.63) | AGTR2LTB4R2AGTR1ABCB11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889036-A | ADMINISTERING 2-ETHOXY-1-((2'-(4,5-DIHYDRO-5-OXO-1,2,4-OXADIAZOL-3-YL)-BIPHE NYL)METHYL-1H-BENZIMIDAZOL-7-CARBOXYLIC ACID | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-30 | — | — | US | claimed |