Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | BAD | Q92934 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLEC | Q15149 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502335 | 0.92 | PPARG (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5MTNR1A | |
| SCHEMBL8502681 | 0.88 | PLA2G2A (0.47) | PLA2G2APLA2G10PLA2G1BPLA2G5PPARG | |
| SCHEMBL8502661 | 0.85 | MTNR1A (0.53) | PLA2G2AMTNR1AMTNR1BPPARGKDM4E | |
| SCHEMBL8502655 | 0.83 | PLA2G2A (0.45) | PLA2G2APLA2G10PLA2G1BPLA2G5PPARG | |
| SCHEMBL2157014 | 0.80 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G1BPLA2G5MTNR1A | |
| SCHEMBL8505425 | 0.80 | PLA2G2A (0.45) | PLA2G2APLA2G10PLA2G1BPLA2G5MTNR1A | |
| SCHEMBL2156559 | 0.79 | MTNR1B (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5MTNR1A | |
| SCHEMBL2156481 | 0.79 | PLA2G2A (0.42) | PLA2G2APLA2G10PLA2G1BPLA2G5PPARG | |
| SCHEMBL8504915 | 0.77 | PLA2G2A (0.68) | PLA2G2APLA2G10PLA2G1BPLA2G5 | |
| SCHEMBL8502436 | 0.77 | MTNR1A (0.46) | PLA2G2APLA2G1BMTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |