Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 19/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.41 |
| ▸ | GABRP | O00591 | 7/20 | 0.33 |
| ▸ | GABRD | O14764 | 7/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.33 |
| ▸ | GABRE | P78334 | 7/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330693 | 0.93 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8328707 | 0.92 | GABRB3 (0.39) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7604165 | 0.90 | GABRB3 (0.36) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8329393 | 0.89 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8587701 | 0.88 | GABRB3 (0.38) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8330780 | 0.83 | CCNE2 (0.38) | — | |
| SCHEMBL8329122 | 0.83 | OPRM1 (0.31) | — | |
| SCHEMBL8328765 | 0.83 | BCL2 (0.31) | — | |
| SCHEMBL8325824 | 0.83 | OPRM1 (0.31) | — | |
| SCHEMBL8330433 | 0.83 | OPRM1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | claimed |