Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507003 | 0.86 | PLA2G2A (0.48) | SRCKMT2AMAPTALDH1A1PLA2G2A | |
| SCHEMBL8503749 | 0.84 | CYP19A1 (0.54) | CCR2KMT2AMAPTNPSR1KDM4E | |
| SCHEMBL8506884 | 0.82 | SRC (0.41) | SRCCCR2KMT2AMITFMAPT | |
| SCHEMBL8504351 | 0.77 | PLA2G2A (0.52) | KMT2AMAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL8505246 | 0.75 | CYP19A1 (0.53) | CCR2KMT2AMAPTNPSR1KDM4E | |
| SCHEMBL8504364 | 0.74 | CYP19A1 (0.51) | CCR2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL8506149 | 0.74 | KDM4E (0.54) | KMT2AMAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL2996558 | 0.73 | ALDH1A1 (0.45) | CCR2KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6254110 | 0.70 | TRPA1 (0.48) | KMT2AKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8506152 | 0.69 | CYP19A1 (0.44) | KMT2AMAPTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750621-B1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1999-07-21 | — | — | EP | claimed |
| EP-0750621-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-01-02 | — | — | EP | claimed |
| WO-1995025110-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-09-21 | — | — | WO | claimed |
| EP-0750621-B1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1999-07-21 | — | — | EP | disclosed |
| US-5783575-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| EP-0750621-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-01-02 | — | — | EP | disclosed |
| US-5536721-A | Thieno[2,3-b-indole derivatives and their use for treating central nervous system diseases related to the metabotropic glutamate receptor system | NOVO NORDISK A/S (DK) | 1996-07-16 | — | — | US | disclosed |
| WO-1995025110-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-09-21 | — | — | WO | disclosed |