Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 14/20 | 0.67 |
| ▸ | GSTA1 | P08263 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.67 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.67 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.67 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.67 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11356320 | 0.89 | GSTP1 (0.56) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL8506841 | 0.86 | GSTP1 (0.64) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL13284005 | 0.85 | GSTP1 (0.70) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL20088748 | 0.84 | GSTP1 (0.77) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL10014667 | 0.83 | GSTP1 (0.80) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL11348841 | 0.81 | GSTP1 (0.47) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL8986308 | 0.80 | GSTP1 (0.71) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| Ethacrynic Acid SCHEMBL26353 | 0.80 | GSTP1 (1.00) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| Ethacrynic Acid SCHEMBL9108011 | 0.80 | GSTP1 (1.00) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL3713736 | 0.80 | GSTP1 (0.80) | GSTP1GSTA1MEN1ABCC3PLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047608-A1 | Method of Treatment and Pharmaceutical Composition for Morning Hypertension | Dharma Laboratories LLC (US) | 2022-02-17 | — | — | US | disclosed |
| EP-3318253-B1 | COMPOSITIONS COMPRISING WNT INHIBITORS FOR TREATING CANCER | SCHMIDT WOLF INGO (DE) | 2020-04-22 | — | — | EP | disclosed |
| US-10259770-B2 | Process for the preparation of ethacrynic acid | STRIDES SHASUN LIMITED (IN) | 2019-04-16 | — | — | US | disclosed |
| US-20180111890-A1 | Process for the Preparation of Ethacrynic Acid | STRIDES SHASUN LIMITED (IN) | 2018-04-26 | — | — | US | disclosed |
| EP-2637653-B1 | COMPOSITIONS COMPRISING ETHACRYNIC ACID AND LENALIDOMIDE AND/OR THALIDOMIDE FOR USE IN TREATING MYELOMA | SCHMIDT-WOLF INGO (DE) | 2018-01-10 | — | — | EP | disclosed |
| EP-2379068-B1 | ETHACRYNIC ACID TO TREAT MYELOMA, LYMPHOMA AND LEUKEMIA | SCHMIDT-WOLF INGO (DE) | 2015-10-28 | — | — | EP | disclosed |
| US-5863948-A | Increasing aqueous humor outflow | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1994022446-A1 | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF NEURONAL CELL DEATH | NOVO NORDISK A/S (DK) | 1994-10-13 | — | — | WO | disclosed |
| EP-0228415-B1 | INCREASING AQUEOUS HUMOR OUTFLOW | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-4757089-A | Increasing aqueous humor outflow | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 1988-07-12 | — | — | US | disclosed |
| US-4261985-A | REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1981-04-14 | — | — | US | disclosed |
| US-4022893-A | Treatment for hypertension | MOYER JOHN H | 1977-05-10 | — | — | US | disclosed |
| US-3959253-A | β-D-glucosyluronic acid derivatives | MERCK & CO., INC. (US) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111890-A1 | Process for the Preparation of Ethacrynic Acid | APEH, DDC, ACMSD | GSTP1 1737/4885GSTA1 1790/4885MEN1 2750/4885 |
| US-10259770-B2 | Process for the preparation of ethacrynic acid | APEH, DDC, ACMSD | GSTP1 1799/4885GSTA1 1824/4885MEN1 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.