Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 15/20 | 0.80 |
| ▸ | GSTA1 | P08263 | 9/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.80 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | RECQL | P46063 | 1/20 | 0.80 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.80 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.80 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.80 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | ATM | Q13315 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethacrynic Acid SCHEMBL29384243 | 0.89 | GSTP1 (1.00) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| Ethacrynic Acid SCHEMBL26353 | 0.89 | GSTP1 (1.00) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| SCHEMBL10014667 | 0.89 | GSTP1 (0.80) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| SCHEMBL10031684 | 0.89 | GSTP1 (0.80) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| Ethacrynic Acid SCHEMBL9108011 | 0.89 | GSTP1 (1.00) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| Ethacrynic Acid SCHEMBL2482896 | 0.88 | GSTP1 (0.97) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| Ethacrynic Acid SCHEMBL3713733 | 0.88 | GSTP1 (0.97) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| SCHEMBL314096 | 0.88 | GSTP1 (0.78) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| SCHEMBL15285485 | 0.88 | GSTP1 (0.78) | GSTP1GSTA1CYP2C9MEN1ABCC3 | |
| Ethacrynic Acid SCHEMBL905726 | 0.88 | GSTP1 (0.97) | GSTP1GSTA1CYP2C9MEN1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016085-B9 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE EPFL (CH) | 2015-12-30 | — | — | EP | disclosed |
| EP-2016085-B1 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE EPFL (CH) | 2015-08-05 | — | — | EP | disclosed |
| US-20150190362-A1 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2015-07-09 | — | — | US | disclosed |
| US-9018199-B2 | Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2015-04-28 | — | — | US | disclosed |
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | The Regents of the The University of California (US) | 2011-12-15 | — | — | US | disclosed |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | The Regents of the The University of California (US) | 2011-12-15 | — | — | US | disclosed |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | The Regents of the The University of California (US) | 2011-12-15 | — | — | US | disclosed |
| WO-2010077310-A2 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY | 2009-12-24 | — | — | US | disclosed |
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | DUKE UNIVERSITY | 2009-12-24 | — | — | US | disclosed |
| US-20090312301-A1 | Transition Metal Complexes for Inhibiting Resistance in the Treatment of Cancer and Metastasis | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2009-12-17 | — | — | US | disclosed |
| EP-2016085-A1 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | EPFL Ecole Polytechnique Fédérale de Lausanne (CH) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007128158-A1 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2007-11-15 | — | — | WO | disclosed |
| EP-0240256-B1 | COMPOUNDS USEFUL IN TREATING SICKLE CELL ANEMIA | MERCK & CO. INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4699926-A | Compounds useful in treating sickle cell anemia | MERCK & CO., INC. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0240256-A2 | Compounds useful in treating sickle cell anemia | MERCK & CO. INC. (US) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318542-A1 | OPHTHAMOLOGICAL DRUGS | QDPR, PTGIR, PDE6C | GSTP1 939/4885GSTA1 1449/4885CYP2C9 492/4885 |
| US-20150190362-A1 | TRANSITION METAL COMPLEXES FOR INHIBITING RESISTANCE IN THE TREATMENT OF CANCER AND METASTASIS | SLC39A3, FABP2, APC | GSTP1 153/4885GSTA1 209/4885CYP2C9 2659/4885 |
| US-20090312301-A1 | Transition Metal Complexes for Inhibiting Resistance in the Treatment of Cancer and Metastasis | SLC39A3, FABP2, SLC30A6 | GSTP1 84/4885GSTA1 144/4885CYP2C9 1997/4885 |
| US-20110306671-A1 | AMIDE DERIVATIVES OF ETHACRYNIC ACID | EPX, TNF, NFKBIA | GSTP1 492/4885GSTA1 258/4885CYP2C9 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.