Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | ADH5 | P11766 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364213 | 0.87 | CYP4Z1 (0.64) | CYP4Z1HDAC2HDAC8HDAC6ADRB1 | |
| Hydrochloric Acid SCHEMBL9367421 | 0.86 | CYP4Z1 (0.63) | CYP4Z1HDAC2HDAC8HDAC6ADRB1 | |
| SCHEMBL9364539 | 0.85 | CYP4Z1 (0.59) | CYP4Z1ADRB1MAPTL3MBTL1ADRB2 | |
| Water SCHEMBL9367484 | 0.84 | CYP4Z1 (0.58) | CYP4Z1ADRB1MAPTL3MBTL1ADRB2 | |
| Water SCHEMBL9367478 | 0.84 | CYP4Z1 (0.58) | CYP4Z1ADRB1MAPTL3MBTL1ADRB2 | |
| SCHEMBL5947724 | 0.83 | EPHX2 (0.64) | CYP4Z1ADRB1MAPTL3MBTL1ADRB2 | |
| SCHEMBL8781065 | 0.82 | CYP4Z1 (0.57) | CYP4Z1ADRB1MAPTL3MBTL1MEN1 | |
| SCHEMBL4674989 | 0.82 | CYP3A4 (0.60) | CYP4Z1GAAADRB1MAPTL3MBTL1 | |
| SCHEMBL7704926 | 0.81 | CYP19A1 (0.64) | CYP4Z1RAB9ASMN1; SMN2GAAHDAC2 | |
| Hydrochloric Acid SCHEMBL8781047 | 0.81 | CYP4Z1 (0.56) | CYP4Z1ADRB1MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292269-A1 | BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS, INC. (CA) | 2010-11-18 | — | — | US | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292269-A1 | BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC3, BIRC2 | CYP4Z1 4313/4885RAB9A 949/4885SMN1; SMN2 3550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.