Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507375 | 0.81 | CHRNB4 (0.36) | SLC6A2SLC6A3SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL8551354 | 0.80 | CHRNB2 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8550383 | 0.76 | GPR119 (0.37) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4962971 | 0.75 | CHRNB2 (0.49) | SLC6A2SLC6A3SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL6233084 | 0.75 | CHRNB2 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7411409 | 0.75 | CHRNB4 (0.36) | SLC6A2SLC6A3SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL7406929 | 0.75 | CHRNB4 (0.36) | SLC6A2SLC6A3SLC6A4CHRNB4CHRNA3 | |
| SCHEMBL7668971 | 0.75 | CHRNB2 (0.40) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8507102 | 0.75 | AKT1 (0.39) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL8508973 | 0.74 | AKT1 (0.42) | CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1997046554-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1997-12-11 | — | — | WO | disclosed |