SCHEMBL850905

SCHEMBL850905

CC(=O)C(=O)OC[C@H](N)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 3/20 0.49
NOS1 P29475 3/20 0.49
NOS2 P35228 3/20 0.49
SLC1A5 Q15758 1/20 0.42
SLC7A5 Q01650 2/20 0.41
GRIK1 P39086 5/20 0.41
IDO1 P14902 1/20 0.40
PTGS1 P23219 2/20 0.39
SLC7A11 Q9UPY5 1/20 0.39
SLC1A3 P43003 5/20 0.38
SLC1A2 P43004 5/20 0.38
SLC1A1 P43005 4/20 0.38
TSHR P16473 1/20 0.38
GRIK2 Q13002 4/20 0.37
GRM8 O00222 1/20 0.37
GRM6 O15303 1/20 0.37
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GSR P00390 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8229301 1.00 NOS3 (0.49) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL12662808 0.84 TSHR (0.39) NOS3NOS1NOS2TSHR
SCHEMBL10187395 0.83 TSHR (0.59) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL1231993 0.83 TSHR (0.59) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL770416 0.82 NOS3 (0.56) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL9980878 0.82 NOS3 (0.56) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL770417 0.82 NOS3 (0.56) NOS3NOS1NOS2SLC1A5SLC7A5
SCHEMBL598363 0.82 NOS3 (0.56) NOS3NOS1NOS2SLC1A5SLC7A5
Hydrogen Sulfide SCHEMBL22463012 0.80 NOS3 (0.55) NOS3NOS1NOS2SLC1A5SLC7A5
Hydrochloric Acid SCHEMBL19209653 0.80 NOS1 (0.55) NOS3NOS1NOS2SLC1A5SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518989-B2 Prodrugs of short-chain fatty acids and treatment methods GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. (US) 2013-08-27 US claimed
US-20110245339-A1 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC (US) 2011-10-06 US claimed
US-20090123388-A1 Prodrugs of Short-Chain Fatty Acids and Treatment Methods MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) 2009-05-14 US claimed
WO-2006076734-A2 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) 2006-07-20 WO claimed
WO-2024123101-A1 MICROORGANISM PRODUCING PURINE NUCLEOTIDE, AND METHOD FOR PRODUCING PURINE NUCLEOTIDE USING SAME 씨제이제일제당 (주) 2024-06-13 WO disclosed
WO-2024123108-A1 PURINE NUCLEOTIDE-PRODUCING MICROORGANISM AND METHOD FOR PRODUCTION OF PURINE NUCLEOTIDE USING SAME 씨제이제일제당 (주) 2024-06-13 WO disclosed
WO-2024123109-A1 MICROORGANISM PRODUCING PURINE NUCLEOTIDES AND METHOD FOR PRODUCING PURINE NUCLEOTIDES USING SAME 씨제이제일제당 (주) 2024-06-13 WO disclosed
US-20230201226-A1 COMBINATION THERAPY FOR REDUCING DRUG-INDUCED NEPHROTOXICITY, DYSLIPIDEMIA AND HYPERGLYCEMIA YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-06-29 US disclosed
EP-3426766-B1 METHOD FOR CONTINUOUS BIOSENSING YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD (IL) 2022-12-28 EP disclosed
US-20220348935-A1 NOVEL GENETICALLY ENGINEERED MICROORGANISM CAPABLE OF GROWING ON FORMATE, METHANOL, METHANE OR CO2 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2022-11-03 US disclosed
US-20210379094-A1 METHOD FOR REDUCING DRUG-INDUCED NEPHROTOXICITY YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2021-12-09 US disclosed
US-20190086391-A1 METHOD AND SYSTEM FOR CONTINUOUS BIOSENSING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2019-03-21 US disclosed
EP-2434421-A2 Compositions and methods for modeling saccharomyces cerevisiae metabolism The Regents of The University of California (US) 2012-03-28 EP disclosed
US-20110245339-A1 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC (US) 2011-10-06 US disclosed
US-20110158980-A1 METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY TRUSTEES OF TUFTS COLLEGE (US) 2011-06-30 US disclosed
WO-2010019434-A1 METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY TRUSTEES OF TUFTS COLLEGE (US) 2010-02-18 WO disclosed
US-20090123388-A1 Prodrugs of Short-Chain Fatty Acids and Treatment Methods MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) 2009-05-14 US disclosed
US-7312049-B2 Total amino acid stabilization during cell-free protein synthesis THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2007-12-25 US disclosed
US-20070004001-A1 Total amino acid stabilization during cell-free protein synthesis THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2007-01-04 US disclosed
WO-2006076734-A2 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) 2006-07-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090123388-A1 Prodrugs of Short-Chain Fatty Acids and Treatment Methods SLC1A5, SPTSSB, SLC27A1 NOS3 836/4885NOS1 902/4885NOS2 840/4885
US-20110245339-A1 PRODRUGS OF SHORT-CHAIN FATTY ACIDS AND TREATMENT METHODS SLC1A5, SPTSSB, SLC27A1 NOS3 836/4885NOS1 902/4885NOS2 840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.