Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 8/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP7 | P09237 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509113 | 0.89 | MMP8 (0.53) | MMP8MMP3HDAC8HDAC3HDAC1 | |
| SCHEMBL8509536 | 0.85 | MMP8 (0.47) | MMP8TSHRMMP3MMP9HDAC8 | |
| SCHEMBL8508383 | 0.82 | MMP8 (0.78) | MMP8TSHR | |
| SCHEMBL8508113 | 0.82 | MMP8 (0.78) | MMP8TSHR | |
| SCHEMBL8509069 | 0.82 | MMP8 (0.62) | MMP8TSHR | |
| SCHEMBL7355911 | 0.79 | MMP8 (0.51) | MMP8POLBMMP3MMP9CNR2 | |
| SCHEMBL8506912 | 0.79 | MMP8 (0.60) | MMP8TSHR | |
| SCHEMBL7351766 | 0.78 | MMP2 (0.59) | MMP8MMP3MMP9MMP2MMP1 | |
| SCHEMBL7361305 | 0.76 | MMP3 (0.46) | POLBMMP3MMP9CNR2MMP2 | |
| SCHEMBL8508880 | 0.76 | MMP8 (0.70) | MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |