Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.55 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.55 |
| ▸ | F2 | P00734 | 4/20 | 0.55 |
| ▸ | PLG | P00747 | 4/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794827 | 0.89 | ST14 (0.71) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851286 | 0.85 | PRSS1 (0.53) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL852012 | 0.84 | PRSS1 (0.51) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851375 | 0.82 | PRSS1 (0.60) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851627 | 0.82 | ALDH1A1 (0.59) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851846 | 0.79 | PRSS1 (0.55) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851847 | 0.77 | PRSS1 (0.54) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851359 | 0.77 | PRSS1 (0.76) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL851607 | 0.76 | ST14 (0.77) | PRSS1PRSS2PRSS3ST14F2 | |
| SCHEMBL852091 | 0.75 | ST14 (0.80) | PRSS1PRSS2PRSS3ST14F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PRSS1 3/4885PRSS2 23/4885PRSS3 11/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PRSS1 3/4885PRSS2 23/4885PRSS3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.