Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | EDNRA | P25101 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.52 |
| ▸ | PPIA | P62937 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650814 | 0.81 | ALDH1A1 (0.72) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL12383540 | 0.77 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL713015 | 0.77 | LMNA (0.71) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL712101 | 0.77 | ALDH1A1 (0.71) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL326633 | 0.77 | ALDH1A1 (0.71) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| Hydrochloric Acid SCHEMBL27575105 | 0.75 | ALDH1A1 (0.69) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL3066836 | 0.75 | LMNA (0.79) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL3476554 | 0.75 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL3002532 | 0.74 | ALDH1A1 (0.68) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL8388562 | 0.74 | PPIA (0.76) | ALDH1A1LMNASMN1; SMN2TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |