Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | EDNRA | P25101 | 1/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | PPIA | P62937 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184078 | 0.85 | ALDH1A1 (0.72) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL183995 | 0.85 | ALDH1A1 (0.72) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| Sulfathiazole SCHEMBL30130508 | 0.85 | ALDH1A1 (1.00) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL8388562 | 0.85 | PPIA (0.76) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL13180843 | 0.85 | ALDH1A1 (0.72) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL1650814 | 0.85 | ALDH1A1 (0.72) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| Sulfathiazole SCHEMBL94165 | 0.85 | ALDH1A1 (1.00) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL326633 | 0.85 | ALDH1A1 (0.71) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| Sulfathiazole SCHEMBL468436 | 0.84 | ALDH1A1 (0.97) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 | |
| Sulfathiazole SCHEMBL2194108 | 0.84 | ALDH1A1 (0.97) | LMNASMN1; SMN2ALDH1A1KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357685-A1 | Sodium Channel Inhibitors | ICAGEN INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140357685-A1 | Sodium Channel Inhibitors | ICAGEN INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140357685-A1 | Sodium Channel Inhibitors | ICAGEN INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-8853250-B2 | Sodium channel inhibitors | ICAGEN, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853250-B2 | Sodium channel inhibitors | ICAGEN, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853250-B2 | Sodium channel inhibitors | ICAGEN, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2175728-B1 | SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2014-09-10 | — | — | EP | disclosed |
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338608-B2 | Inhibitors of ion channels | ICAGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2175728-A1 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009012241-A1 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| EP-1945029-A2 | INHIBITORS OF ION CHANNELS | Icagen, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | ICAGEN (US) | 2007-06-14 | — | — | US | disclosed |
| WO-2007056099-A2 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20050176712-A1 | Integrin expression inhibitor | EISAI CO., LTD. | 2005-08-11 | — | — | US | disclosed |
| US-20040018192-A1 | Integrin expression inhibitors | EISAI CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1258252-A1 | INTEGRIN EXPRESSION INHIBITORS | Eisai Co., Ltd. (JP) | 2002-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176712-A1 | Integrin expression inhibitor | ITGB5, ITGB1, ITGB2 | LMNA 3673/4885SMN1; SMN2 2639/4885ALDH1A1 1256/4885 |
| US-20070135493-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | LMNA 3442/4885SMN1; SMN2 445/4885ALDH1A1 3113/4885 |
| US-20040018192-A1 | Integrin expression inhibitors | ITGB1, ITGB4, ITGB5 | LMNA 3427/4885SMN1; SMN2 2404/4885ALDH1A1 1266/4885 |
| US-20140357685-A1 | Sodium Channel Inhibitors | TRPV1, SCN1A, SCN2A | LMNA 3041/4885SMN1; SMN2 326/4885ALDH1A1 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.