Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2347014 | 0.81 | TDP1 (0.44) | TTRMEN1KMT2ARNASEH1GRIN2D | |
| SCHEMBL19627732 | 0.80 | TDP1 (0.40) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL21120426 | 0.79 | ALDH1A1 (0.46) | TTRMEN1KMT2AKMOGRIN2D | |
| SCHEMBL14768691 | 0.78 | MEN1 (0.40) | MEN1KMT2AKMOGRIN2DGRIN3B | |
| SCHEMBL536122 | 0.78 | TDP1 (0.46) | TTRMEN1KMT2AKMOGRIN2D | |
| SCHEMBL19283132 | 0.76 | PKM (0.50) | MEN1KMT2ARNASEH1LMNAALDH1A1 | |
| SCHEMBL14354477 | 0.73 | TPMT (0.49) | MEN1KMT2AKMOLMNAALDH1A1 | |
| SCHEMBL31071679 | 0.72 | MEN1 (0.42) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL2224615 | 0.72 | MEN1 (0.42) | TTRAKR1C2AKR1C1AKR1C4AKR1C3 | |
| Clopyralid SCHEMBL29371357 | 0.71 | KMT2A (0.50) | MEN1KMT2AALDH1A1DPP4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643312-B1 | MICROBICIDAL HETEROCYCLES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-09-10 | — | — | EP | disclosed |
| US-8748431-B2 | Microbicidal heterocycles | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-10 | — | — | US | disclosed |
| US-20130324544-A1 | MICROBICIDAL HETEROCYCLES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-12-05 | — | — | US | disclosed |
| EP-2643312-A1 | MICROBICIDAL HETEROCYCLES | Syngenta Participations AG (CH) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069633-A1 | MICROBICIDAL HETEROCYCLES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324544-A1 | MICROBICIDAL HETEROCYCLES | CYP1A1, CYP1B1, CYP51A1 | TTR 3468/4885AKR1C2 1038/4885AKR1C1 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.