Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510921 | 0.84 | TBK1 (0.49) | GPR119ALOX5SYKDDB1CRBN | |
| SCHEMBL8515822 | 0.83 | PRKD1 (0.46) | HRH4PRKD1PRKD2 | |
| SCHEMBL3267870 | 0.76 | CKS1B (0.65) | GPR119CKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL27091045 | 0.75 | CKS1B (0.53) | GPR119CKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL2015195 | 0.75 | CKS1B (0.46) | GPR119CKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL1580957 | 0.74 | PRKD1 (0.55) | GPR119CKS1BSKP1SKP2SYK | |
| SCHEMBL2545603 | 0.73 | CKS1B (0.52) | GPR119CKS1BSKP1SKP2MAP4K4 | |
| SCHEMBL8514479 | 0.72 | TBK1 (0.50) | GPR119CKS1BSKP1SKP2DDB1 | |
| SCHEMBL1592040 | 0.72 | PRKD1 (0.63) | SYKPRKD1PRKD2TBK1 | |
| SCHEMBL1580476 | 0.72 | PRKD1 (0.76) | SYKPRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |