Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 14/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 7/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511658 | 0.83 | GPR119 (0.46) | PRKD1PRKD2HRH4 | |
| SCHEMBL8515459 | 0.82 | PRKD1 (0.46) | PRKD1PRKD2ADRB1 | |
| SCHEMBL1588027 | 0.72 | HRH4 (0.71) | PRKD1PRKD2HRH4HRH3 | |
| SCHEMBL1588677 | 0.67 | HRH4 (0.67) | HRH4HRH3 | |
| SCHEMBL8515571 | 0.67 | CYP1A2 (0.47) | PRKD1PRKD2ADRB1CYP1A2CYP2C9 | |
| SCHEMBL1579219 | 0.67 | PRKD1 (0.71) | PRKD1PRKD2ADRB1 | |
| SCHEMBL8515830 | 0.67 | PRKD1 (0.45) | PRKD1PRKD2ADRB1 | |
| Hydrochloric Acid SCHEMBL8514610 | 0.66 | CYP1A2 (0.46) | PRKD1PRKD2ADRB1CYP1A2CYP2C9 | |
| SCHEMBL1579273 | 0.66 | PRKD1 (0.79) | PRKD1PRKD2ADRB1 | |
| SCHEMBL3272539 | 0.66 | PIK3CD (0.52) | ADRB1CYP1A2CYP2C9HSD17B10HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |