Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.65 |
| ▸ | SKP1 | P63208 | 2/20 | 0.65 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545603 | 0.85 | CKS1B (0.52) | CKS1BSKP1SKP2ACHEGBA1 | |
| SCHEMBL27091045 | 0.84 | CKS1B (0.53) | CKS1BSKP1SKP2ACHEGBA1 | |
| SCHEMBL30831564 | 0.84 | CYP2C19 (0.65) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL26993905 | 0.84 | CYP2C19 (0.65) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL3443191 | 0.82 | CKS1B (0.64) | CKS1BSKP1SKP2ACHEGBA1 | |
| SCHEMBL3275117 | 0.81 | CKS1B (0.65) | CKS1BSKP1SKP2ACHEGBA1 | |
| SCHEMBL3269283 | 0.81 | CKS1B (0.48) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL3782979 | 0.81 | MAP4K4 (0.61) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL31453948 | 0.81 | GPR119 (0.56) | CKS1BSKP1SKP2ACHEGPR119 | |
| SCHEMBL1320120 | 0.81 | GPR119 (0.56) | CKS1BSKP1SKP2ACHEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981010-A | Amide compound | TAKEDA PHARMACEUTICAL | 2011-02-23 | — | — | CN | disclosed |
| US-20100234389-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-16 | — | — | US | disclosed |
| EP-2199282-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2010-06-23 | — | — | EP | disclosed |
| US-20090163508-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234389-A1 | AMIDE COMPOUND | FAAH, FAAH2, NAAA | CKS1B 3175/4885SKP1 3469/4885SKP2 3535/4885 |
| US-20090163508-A1 | AMIDE COMPOUND | FAAH, FAAH2, NAAA | CKS1B 3175/4885SKP1 3469/4885SKP2 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.