Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.44 |
| ▸ | RARA | P10276 | 3/20 | 0.44 |
| ▸ | RARG | P13631 | 3/20 | 0.39 |
| ▸ | AKT1 | P31749 | 12/20 | 0.38 |
| ▸ | AKT2 | P31751 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8515237 | 0.99 | RARB (0.44) | RARBRARARARGAKT1AKT2 | |
| SCHEMBL8514830 | 0.84 | RARA (0.40) | RARBRARARARGAKT1AKT2 | |
| SCHEMBL8515374 | 0.84 | RARB (0.60) | RARBRARARARGAKT1AKT2 | |
| SCHEMBL8513591 | 0.82 | RARA (0.38) | RARBRARARARGAKT1AKT2 | |
| Hydrochloric Acid SCHEMBL8514603 | 0.82 | RARA (0.58) | RARBRARARARGAKT1AKT2 | |
| Hydrochloric Acid SCHEMBL8612658 | 0.82 | RARA (0.58) | RARBRARARARGAKT1AKT2 | |
| SCHEMBL8514253 | 0.82 | NPC1 (0.55) | RARBRARARARGNPC1MEN1 | |
| Hydrochloric Acid SCHEMBL8510905 | 0.81 | RARA (0.38) | RARBRARARARGAKT1AKT2 | |
| SCHEMBL8515330 | 0.80 | RARB (0.46) | RARBRARARARGNPC1MEN1 | |
| SCHEMBL8515254 | 0.79 | RARB (0.51) | RARBRARARARGNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |