Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511601 | 0.85 | ACHE (0.47) | PTPN11ACHECKS1BSKP1SKP2 | |
| SCHEMBL8513449 | 0.80 | S1PR1 (0.42) | PIK3CATLR9TLR7 | |
| SCHEMBL12804909 | 0.77 | PIK3CA (0.48) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL2384006 | 0.75 | GPR119 (0.48) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL8515547 | 0.74 | ACHE (0.47) | PTPN11ACHECKS1BSKP1SKP2 | |
| SCHEMBL27029508 | 0.74 | CKS1B (0.50) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL30718251 | 0.74 | CKS1B (0.50) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL2033275 | 0.74 | PIK3CA (0.46) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL2015674 | 0.73 | PIK3CA (0.45) | PIK3CAPTPN11ACHEKITCKS1B | |
| SCHEMBL8510959 | 0.71 | CKS1B (0.44) | CKS1BSKP1SKP2GPR119SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |