Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2081383 | 0.85 | TNF (0.51) | TNFRAB9ANOD1SMN1; SMN2TDP1 | |
| SCHEMBL4166290 | 0.81 | ALDH1A1 (0.67) | TNFRAB9ANOD1SMN1; SMN2MAPT | |
| SCHEMBL11888841 | 0.80 | SMN1; SMN2 (0.51) | TNFRAB9ANOD1SMN1; SMN2MAPT | |
| SCHEMBL8516111 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1POLBPKMTSHR | |
| SCHEMBL2080681 | 0.78 | TP53 (0.65) | SMN1; SMN2MAPTTP53ALDH1A1CNR2 | |
| SCHEMBL2081742 | 0.78 | ALDH1A1 (0.73) | SMN1; SMN2MAPTTP53MAPK1HTT | |
| SCHEMBL5246389 | 0.75 | MAPT (0.66) | SMN1; SMN2MAPTTP53POLBTSHR | |
| SCHEMBL29060784 | 0.74 | PKM (0.66) | SMN1; SMN2TDP1MAPK1ALDH1A1POLB | |
| SCHEMBL18711646 | 0.73 | ALDH1A1 (0.76) | RAB9AMAPTMAPK1ALDH1A1PKM | |
| SCHEMBL2079086 | 0.73 | NPC1 (0.76) | RAB9ASMN1; SMN2MAPTTP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |