Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | P2RX7 | Q99572 | 15/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195590 | 0.91 | NPC1 (0.73) | NPC1RAB9AP2RX7TSHRMEN1 | |
| SCHEMBL11247967 | 0.87 | CYP2C9 (0.56) | NPC1RAB9AP2RX7TSHRPTGDR2 | |
| SCHEMBL11539322 | 0.87 | RAB9A (0.58) | NPC1RAB9AP2RX7TSHRMEN1 | |
| SCHEMBL1194345 | 0.84 | NPC1 (0.56) | NPC1RAB9AP2RX7PTGDR2 | |
| SCHEMBL11264646 | 0.84 | NPC1 (0.56) | NPC1RAB9AP2RX7MEN1KMT2A | |
| SCHEMBL11254639 | 0.82 | PDE4D (0.59) | NPC1RAB9AP2RX7TSHRPTGDR2 | |
| SCHEMBL1195159 | 0.81 | CYP2C9 (0.62) | NPC1RAB9AP2RX7TSHRMEN1 | |
| SCHEMBL11240990 | 0.81 | PTGDR2 (0.51) | NPC1RAB9AP2RX7TSHRPTGDR2 | |
| SCHEMBL1194273 | 0.80 | P2RX7 (0.73) | P2RX7 | |
| SCHEMBL11249174 | 0.79 | NPC1 (0.69) | NPC1RAB9AP2RX7TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | claimed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | claimed |
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |
| US-4325962-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS | BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4146721-A | ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1979-03-27 | — | — | US | disclosed |