Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30125488 | 1.00 | PDK2 (0.47) | PDK2PTPRCPTPN1CHEK1ALOX5AP | |
| SCHEMBL1812200 | 0.92 | PDK2 (0.48) | PDK2PTPRCPTPN1CHEK1ALOX5AP | |
| SCHEMBL164197 | 0.89 | EGFR (0.38) | PDK2CHEK1MEN1POLBKMT2A | |
| SCHEMBL1010811 | 0.89 | EGFR (0.38) | PDK2CHEK1MEN1POLBKMT2A | |
| SCHEMBL9898302 | 0.89 | HSP90AA1 (0.44) | PDK2PTPRCPTPN1CHEK1ALOX5AP | |
| SCHEMBL8511775 | 0.87 | PDK2 (0.39) | PDK2PTPRCPTPN1PGRNR3C1 | |
| SCHEMBL1815053 | 0.87 | PDK2 (0.42) | PDK2ALOX5APFEN1PGRAR | |
| SCHEMBL30125362 | 0.86 | PDK2 (0.40) | PDK2PTPN1PGRARHSP90AA1 | |
| SCHEMBL165110 | 0.86 | PDK2 (0.40) | PDK2PTPN1PGRARHSP90AA1 | |
| SCHEMBL1012466 | 0.86 | FYN (0.37) | PDK2MAPK1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313996-B1 | INDENONAPHTHOPYRANS HAVING TRIALKYLSILYL AND ETHYLENICALLY UNSATURATED GROUPS | TRANSITIONS OPTICAL LTD (IE) | 2026-05-06 | — | — | EP | disclosed |
| US-20240376132-A1 | Indenonaphthopyrans Having Trialkylsilyl and Ethylenically Unsaturated Groups | TRANSITIONS OPTICAL, LTD. (IE) | 2024-11-14 | — | — | US | disclosed |
| EP-4313996-A1 | INDENONAPHTHOPYRANS HAVING TRIALKYLSILYL AND ETHYLENICALLY UNSATURATED GROUPS | Transitions Optical, Ltd. (IE) | 2024-02-07 | — | — | EP | disclosed |
| CN-117043168-A | Indenonaphthopyrans having trialkylsilyl groups and ethylenically unsaturated groups | 光学转变有限公司 | 2023-11-10 | — | — | CN | disclosed |
| US-9139552-B2 | Indeno-fused naphthopyrans having ethylenically unsaturated groups | TRANSITIONS OPTICAL, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| WO-2013090220-A1 | INDENO-FUSED NAPHTHOPYRANS HAVING ETHYLENICALLY UNSATURATED GROUPS | PPG INDUSTRIES, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| US-20120132870-A1 | Indeno-Fused Naphthopyrans Having Ethylenically Unsaturated Groups | TRANSITIONS OPTICAL INC. (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376132-A1 | Indenonaphthopyrans Having Trialkylsilyl and Ethylenically Unsaturated Groups | B3GNT2, ERLIN1, RPN1 | PDK2 1689/4885PTPRC 1170/4885PTPN1 1229/4885 |
| US-20120132870-A1 | Indeno-Fused Naphthopyrans Having Ethylenically Unsaturated Groups | ACR, INTS6, B3GNT2 | PDK2 2446/4885PTPRC 1216/4885PTPN1 1089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.