Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1534311 | 0.80 | HTR2A (0.67) | HTR2AHRH1AOC3RIPK1CHRM2 | |
| SCHEMBL1534201 | 0.80 | HTR2A (0.67) | HTR2AHRH1AOC3RIPK1CHRM2 | |
| SCHEMBL1534343 | 0.80 | HTR2A (0.67) | HTR2AHRH1AOC3RIPK1CHRM2 | |
| SCHEMBL5463519 | 0.78 | UTS2R (0.46) | HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL4377637 | 0.78 | HTR2A (0.64) | HTR2AHRH1AOC3RIPK1CHRM2 | |
| SCHEMBL317303 | 0.78 | LMNA (0.40) | HTR2AAOC3RIPK1CHRM2SLC6A4 | |
| SCHEMBL22399245 | 0.78 | LMNA (0.40) | HTR2AAOC3RIPK1CHRM2SLC6A4 | |
| SCHEMBL6829520 | 0.77 | AOC3 (0.58) | HTR2AHRH1AOC3SLC6A2SLC6A4 | |
| SCHEMBL188905 | 0.77 | HTR2A (0.42) | HTR2AHRH1AOC3RIPK1 | |
| SCHEMBL4733883 | 0.77 | CHRM2 (0.49) | HTR2AHRH1CHRM2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288396-B2 | Pyrimidopyrimidoindazole derivative | MSDKK (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20120134955-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120134955-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | WEE1, WEE2, DCK | HTR2A 4687/4885HRH1 2283/4885AOC3 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.