Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 16/20 | 0.64 |
| ▸ | F2 | P00734 | 13/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 13/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 13/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 13/20 | 0.64 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | FURIN | P09958 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851902 | 0.88 | ST14 (0.59) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851819 | 0.84 | PDE4A (0.45) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851791 | 0.82 | PDE4A (0.43) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851666 | 0.79 | PARP15 (0.51) | — | |
| SCHEMBL3791103 | 0.79 | ST14 (1.00) | ST14F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL8994944 | 0.77 | PRSS1 (0.68) | ST14F2PRSS1PLAUF10 | |
| Hydrochloric Acid SCHEMBL8994879 | 0.75 | PRSS1 (0.62) | ST14F2PRSS1PLAU | |
| SCHEMBL851104 | 0.75 | F2 (0.41) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3789265 | 0.73 | ST14 (0.83) | ST14F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851832 | 0.73 | ST14 (0.54) | ST14F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F2 112/4885PRSS1 3/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | ST14 216/4885F2 112/4885PRSS1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.