Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | ACACB | O00763 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015994 | 0.90 | RARA (0.50) | RARARARBRETKIF18AGPR119 | |
| SCHEMBL12804321 | 0.86 | CKS1B (0.51) | RARARARBRETKIF18AGPR119 | |
| SCHEMBL8514114 | 0.85 | CYP11B2 (0.47) | CYP11B2SCD5HDAC2RETACACB | |
| SCHEMBL2016042 | 0.84 | CKS1B (0.48) | RARARARBRETKIF18AGPR119 | |
| SCHEMBL12633005 | 0.83 | RARA (0.44) | RARARARBKIF18AGPR119CKS1B | |
| SCHEMBL8511358 | 0.83 | CYP11B2 (0.46) | CYP11B2SCD5HDAC2RETACACB | |
| SCHEMBL2016854 | 0.81 | CKS1B (0.45) | RARARARBRETKIF18AGPR119 | |
| SCHEMBL12633907 | 0.80 | CKS1B (0.46) | RARARARBRETKIF18AGPR119 | |
| Hydrochloric Acid SCHEMBL8514984 | 0.80 | TBK1 (0.42) | RARARARBHDAC1KIF18AGPR119 | |
| SCHEMBL2015302 | 0.79 | CKS1B (0.43) | RARARARBRETKIF18AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |