Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.39 |
| ▸ | JAK3 | P52333 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515658 | 1.00 | JAK1 (0.39) | JAK1JAK3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8511513 | 0.85 | KDM4E (0.38) | JAK1JAK3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8515188 | 0.85 | LMNA (0.47) | KDM4EALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL8512190 | 0.83 | ALDH1A1 (0.41) | JAK1JAK3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8512305 | 0.80 | PLAT (0.41) | JAK1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL8515649 | 0.79 | GPR119 (0.35) | JAK3GPR119JAK2 | |
| SCHEMBL8511865 | 0.79 | GPR119 (0.35) | JAK3GPR119JAK2 | |
| SCHEMBL8515570 | 0.77 | GPR119 (0.38) | GPR119JAK2 | |
| SCHEMBL8612817 | 0.74 | GPR119 (0.43) | GPR119 | |
| SCHEMBL8514825 | 0.74 | GPR119 (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643310-A1 | 4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS | Pfizer Inc (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069948-A1 | 4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS | PFIZER INC. (US) | 2012-05-31 | — | — | WO | disclosed |