Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514061 | 0.83 | DHODH (0.42) | CYP3A4DHODH | |
| SCHEMBL8515898 | 0.79 | CYP3A4 (0.43) | CYP3A4DHODH | |
| SCHEMBL8515893 | 0.79 | CYP3A4 (0.44) | CYP3A4DHODH | |
| SCHEMBL8511573 | 0.76 | KDM4E (0.42) | HSD17B10MCHR1KDM4EPOLBTSHR | |
| SCHEMBL8514255 | 0.73 | PDE10A (0.44) | DHODHMAPTTSHR | |
| SCHEMBL8514251 | 0.73 | PDE10A (0.44) | DHODHMAPTTSHR | |
| SCHEMBL8512120 | 0.70 | SCN9A (0.45) | DHODHMAPT | |
| SCHEMBL8512116 | 0.66 | PTGDR2 (0.37) | — | |
| SCHEMBL8514929 | 0.65 | DHODH (0.49) | DHODHMAPTTSHR | |
| SCHEMBL8514932 | 0.65 | DHODH (0.49) | DHODHMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |