Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 2/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515893 | 0.93 | CYP3A4 (0.44) | CYP3A4DHODHPTGDR2TRPM8P2RY14 | |
| SCHEMBL8514061 | 0.84 | DHODH (0.42) | CYP3A4DHODHPTGDR2TRPM8P2RY14 | |
| SCHEMBL8514758 | 0.80 | DHODH (0.44) | DHODHPTGFRSCN10A | |
| SCHEMBL8515434 | 0.79 | HSD17B10 (0.43) | CYP3A4DHODH | |
| SCHEMBL8514251 | 0.73 | PDE10A (0.44) | DHODHTRPM8PTGFR | |
| SCHEMBL8514255 | 0.73 | PDE10A (0.44) | DHODHTRPM8PTGFR | |
| SCHEMBL8515384 | 0.72 | ACP1 (0.44) | DHODHPTGFRSCN10A | |
| SCHEMBL8512120 | 0.70 | SCN9A (0.45) | DHODHTRPM8PTGFR | |
| SCHEMBL8534985 | 0.67 | MAPK8 (0.40) | CYP3A4DHODHPTGDR2 | |
| SCHEMBL8535303 | 0.66 | MAT2A (0.55) | CYP3A4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |