Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 15/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 8/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | DKK1 | O94907 | 1/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515830 | 0.85 | PRKD1 (0.45) | PRKD1PRKD2ADRB1DKK1MYLK4 | |
| SCHEMBL8510921 | 0.83 | TBK1 (0.49) | DKK1STK17A | |
| SCHEMBL8515822 | 0.82 | PRKD1 (0.46) | PRKD1PRKD2ADRB1 | |
| SCHEMBL8511121 | 0.82 | KMO (0.46) | PRKD1PRKD2ADRB1DKK1MYLK4 | |
| Hydrochloric Acid SCHEMBL8533322 | 0.82 | KMO (0.46) | PRKD1PRKD2ADRB1DKK1MYLK4 | |
| SCHEMBL8512423 | 0.76 | ADRB1 (0.42) | ADRB1DKK1MYLK4STK17AROCK2 | |
| Hydrochloric Acid SCHEMBL8511182 | 0.75 | ADRB1 (0.41) | ADRB1DKK1MYLK4STK17AROCK2 | |
| SCHEMBL8511790 | 0.75 | ROCK2 (0.41) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| Hydrochloric Acid SCHEMBL8512525 | 0.74 | ROCK2 (0.41) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| Hydrochloric Acid SCHEMBL8511580 | 0.74 | ROCK2 (0.41) | PRKD1PRKD2ADRB1PRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |