Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3851699 | 0.87 | DAO (0.50) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL9156375 | 0.86 | DAO (0.48) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL9157240 | 0.84 | TRPV4 (0.43) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL9351438 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL27344647 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL9620664 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL12224352 | 0.78 | NFKB1 (0.50) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL9154236 | 0.78 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL10460111 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1TP53PKM | |
| SCHEMBL10553282 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |