Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100087 | 0.93 | POLB (0.63) | POLBEPHX2PPARGPPARAHDAC3 | |
| SCHEMBL9607170 | 0.83 | RAB9A (0.51) | EPHX2PPARGPPARAHDAC3HDAC1 | |
| SCHEMBL8514914 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL27809101 | 0.81 | POLB (0.62) | POLBEPHX2PPARGPPARAHDAC3 | |
| SCHEMBL17290763 | 0.80 | HDAC3 (0.52) | POLBEPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL4994157 | 0.80 | ALDH1A1 (0.51) | POLBSMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL20351685 | 0.80 | POLB (0.60) | POLBEPHX2PPARGPPARAHDAC3 | |
| SCHEMBL508864 | 0.79 | MRGPRX4 (0.57) | EPHX2HDAC3HDAC1HDAC2HDAC4 | |
| SCHEMBL1940297 | 0.79 | POLB (0.62) | POLBEPHX2PPARGPPARAHDAC4 | |
| SCHEMBL2743506 | 0.78 | POLB (0.56) | POLBEPHX2PPARGPPARAHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |