Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 16/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 13/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | CDK1 | P06493 | 2/20 | 0.66 |
| ▸ | CDK4 | P11802 | 2/20 | 0.66 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.66 |
| ▸ | CCND1 | P24385 | 2/20 | 0.66 |
| ▸ | ABL2 | P42684 | 2/20 | 0.66 |
| ▸ | GSK3A | P49840 | 2/20 | 0.66 |
| ▸ | CDK7 | P50613 | 2/20 | 0.66 |
| ▸ | CCNH | P51946 | 2/20 | 0.66 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515811 | 0.90 | CDK9 (0.80) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8516163 | 0.84 | CDK9 (0.81) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4435897 | 0.84 | CCNT1 (0.69) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL17022953 | 0.81 | CDK9 (0.67) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8516573 | 0.80 | CYP1A2 (0.69) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8516178 | 0.79 | CDK9 (0.79) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8515826 | 0.79 | CDK9 (0.76) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8513621 | 0.79 | CYP1A2 (0.74) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8514297 | 0.79 | CDK9 (0.72) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL2029081 | 0.78 | CDK9 (0.61) | CDK9CCNT1MAP4K4CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137166-B1 | 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2012-05-30 | — | — | EP | claimed |