Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 5/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012548 | 0.75 | CA1 (0.51) | RXRARXRBCA1CA2CA12 | |
| SCHEMBL8516177 | 0.72 | CA2 (0.40) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL8514336 | 0.72 | PTGES2 (0.41) | CA1CA2CA12CA9CA14 | |
| SCHEMBL29625290 | 0.72 | MAP4K4 (0.54) | RXRARXRBMAP4K4SRD5A2TSHR | |
| SCHEMBL3312743 | 0.72 | CA1 (0.56) | CA1CA2CA12CA9CA14 | |
| SCHEMBL16749641 | 0.71 | MAP4K4 (0.57) | RXRARXRBCA1CA2CA12 | |
| SCHEMBL6165621 | 0.71 | CA12 (0.50) | RXRARXRBCA1CA2CA12 | |
| SCHEMBL940238 | 0.70 | MMP2 (0.61) | CA1CA2CA12CA9CA14 | |
| SCHEMBL28380155 | 0.69 | TP53 (0.55) | RXRARXRBCA1CA2CA12 | |
| SCHEMBL7952991 | 0.69 | APEX1 (0.67) | CA1CA2CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457906-A1 | Derivatives of 1,2,4-benzothiadiazine dioxide, their preparation and use as allosteric modulators of the AMPA receptor | Universita'del Salento (IT) | 2012-05-30 | — | — | EP | disclosed |