Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 13/20 | 0.64 |
| ▸ | CA2 | P00918 | 13/20 | 0.64 |
| ▸ | CA4 | P22748 | 6/20 | 0.57 |
| ▸ | CA9 | Q16790 | 11/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 6/20 | 0.52 |
| ▸ | CA6 | P23280 | 5/20 | 0.52 |
| ▸ | CA5A | P35218 | 5/20 | 0.52 |
| ▸ | CA7 | P43166 | 5/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.52 |
| ▸ | CA3 | P07451 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21999840 | 0.82 | CA1 (0.48) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL77983 | 0.82 | CA1 (0.67) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL8516285 | 0.81 | CA1 (0.52) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL1804696 | 0.80 | CA1 (0.62) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL1957301 | 0.80 | CA1 (0.52) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL9518035 | 0.80 | APEX1 (1.00) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL1804698 | 0.78 | CA1 (1.00) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL31070438 | 0.78 | CA1 (1.00) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL2919577 | 0.78 | CA2 (0.48) | APEX1POLBTDP1L3MBTL1CA1 | |
| SCHEMBL11689095 | 0.75 | ACLY (0.46) | APEX1POLBTDP1L3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121470-A | Preparation method of benzothiadiazine-1, 1-dioxide compound | 天津理工大学 | 2021-07-16 | — | — | CN | disclosed |
| CN-1081633-C | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 2002-03-27 | — | — | CN | disclosed |
| US-6242443-B1 | 1,2,4-benzothiadiazine derivatives, their preparation and use | NOVO NORDISK AIS (DK) | 2001-06-05 | — | — | US | disclosed |
| CN-1222910-A | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 1999-07-14 | — | — | CN | disclosed |
| EP-0906297-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049692-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-12-31 | — | — | WO | disclosed |