Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL8516149

CCn1cc(-c2nc3ccc(C(=O)OC)cc3n(CCOCCN)c2=O)c2ccccc21.O=C(O)C(F)(F)F

nearest known ligand 0.45

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.45
ACSS2 Q9NR19 3/20 0.43
CA12 O43570 3/20 0.42
CA1 P00915 3/20 0.42
CA2 P00918 3/20 0.42
CA9 Q16790 3/20 0.42
PTGER4 P35408 4/20 0.39
USP2 O75604 4/20 0.38
CYP1A2 P05177 4/20 0.38
CYP3A4 P08684 4/20 0.38
CYP2C19 P33261 3/20 0.38
CYP2C9 P11712 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HBB P68871 1/20 0.38
ALDH1A1 P00352 3/20 0.38
CLK4 Q9HAZ1 1/20 0.38
NR4A2 P43354 1/20 0.37
TSHR P16473 2/20 0.36
CASP1 P29466 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8517280 0.92 CFTR (0.41) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516150 0.92 CFTR (0.47) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516660 0.90 CFTR (0.46) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8515718 0.90 CFTR (0.44) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8367871 0.89 CFTR (0.46) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516447 0.88 ALDH1A1 (0.44) CFTRUSP2CYP1A2CYP3A4CYP2C9
Trifluoroacetic Acid SCHEMBL8515856 0.86 CA12 (0.38) CA12CA1CA2CA9PTGER4
Trifluoroacetic Acid SCHEMBL8368543 0.84 CFTR (0.42) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8365292 0.83 CFTR (0.44) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8365298 0.83 CFTR (0.45) CFTRACSS2CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO claimed
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO disclosed