Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL8516150

CCn1cc(-c2nc3ccc(C(=O)OC)cc3n(CCCN)c2=O)c2ccccc21.O=C(O)C(F)(F)F

nearest known ligand 0.47

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.47
ACSS2 Q9NR19 3/20 0.45
CA12 O43570 4/20 0.43
CA1 P00915 4/20 0.43
CA2 P00918 4/20 0.43
CA9 Q16790 4/20 0.43
USP2 O75604 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
NR4A2 P43354 1/20 0.39
TLR8 Q9NR97 1/20 0.38
ITK Q08881 1/20 0.38
PTGER4 P35408 4/20 0.38
PADI4 Q9UM07 1/20 0.37
JAK2 O60674 1/20 0.37
JAK1 P23458 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8516660 0.97 CFTR (0.46) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516149 0.92 CFTR (0.45) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8368543 0.92 CFTR (0.42) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8367871 0.91 CFTR (0.46) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8515708 0.90 CFTR (0.46) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516818 0.89 CFTR (0.42) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8515904 0.88 ALDH1A1 (0.45) CFTRUSP2ALDH1A1CYP1A2CYP3A4
Trifluoroacetic Acid SCHEMBL8516484 0.87 CFTR (0.45) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8365292 0.85 CFTR (0.44) CFTRACSS2CA12CA1CA2
Trifluoroacetic Acid SCHEMBL8516292 0.85 ALDH1A1 (0.44) CFTRUSP2ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO claimed
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO disclosed