Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516183 | 1.00 | CXCR2 (0.46) | CXCR2CXCR1MAPTLMNAPKM | |
| SCHEMBL7737472 | 0.84 | CXCR2 (0.67) | CXCR2CXCR1MAPTLMNAMEN1 | |
| SCHEMBL7938088 | 0.84 | CXCR2 (0.67) | CXCR2CXCR1MAPTLMNAMEN1 | |
| SCHEMBL7751145 | 0.83 | CHRNB2 (0.43) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL7751139 | 0.83 | CHRNB2 (0.43) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL6836869 | 0.70 | KMT2A (0.68) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL7743008 | 0.68 | CXCR2 (0.43) | CXCR2CXCR1MAPTLMNAPKM | |
| SCHEMBL7743014 | 0.68 | CXCR2 (0.43) | CXCR2CXCR1MAPTLMNAPKM | |
| SCHEMBL6823227 | 0.67 | KMT2A (0.67) | CXCR2CXCR1MAPTLMNAMEN1 | |
| SCHEMBL28438459 | 0.66 | RAB9A (0.59) | CXCR2CXCR1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948330-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0948330-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998005328-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |