Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | NPM1 | P06748 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL8367899 | 0.92 | LMNA (0.44) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8368538 | 0.84 | CFTR (0.42) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8362812 | 0.84 | LMNA (0.44) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8362203 | 0.82 | CFTR (0.41) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8366714 | 0.82 | LMNA (0.43) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8367897 | 0.81 | CFTR (0.40) | LMNAHTTPOLBUSP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8368691 | 0.80 | TP53 (0.39) | POLBUSP2PDE4BPDE4DMAPT | |
| Trifluoroacetic Acid SCHEMBL8516160 | 0.80 | PAX8 (0.47) | LMNAHTTPOLBUSP2PDE4A | |
| Trifluoroacetic Acid SCHEMBL7815420 | 0.79 | PDE4A (0.45) | HTTPOLBUSP2PDE4APDE4B | |
| Trifluoroacetic Acid SCHEMBL8366749 | 0.78 | LMNA (0.41) | LMNAHTTPOLBUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999046260-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | claimed |