Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1070099 | 0.93 | HRH1 (0.62) | HRH1RIPK1SLC6A4SLC6A2FFAR1 | |
| SCHEMBL1067253 | 0.85 | HRH1 (0.67) | HRH1RIPK1SLC6A4SLC6A2FFAR1 | |
| SCHEMBL6552750 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2PPARA | |
| SCHEMBL321170 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2PPARA | |
| SCHEMBL10875308 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2PPARA | |
| SCHEMBL7653319 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2FFAR1 | |
| SCHEMBL11524632 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2FFAR1 | |
| SCHEMBL407448 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2PPARA | |
| SCHEMBL20895821 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2PPARA | |
| SCHEMBL11664363 | 0.83 | HRH1 (0.59) | HRH1RIPK1SLC6A4SLC6A2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841919-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-24 | — | — | EP | disclosed |
| EP-0841919-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |