SCHEMBL8516774

SCHEMBL8516774

c1ccc2c(c1)Oc1ccccc1C2C1c2ccccc2-c2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54
ATM Q13315 2/20 0.45
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
CYP2C9 P11712 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19458502 0.90 MAOA (0.64) MAOAMAOBATMHDAC3HDAC4
SCHEMBL4382002 0.83 MAOA (0.47) MAOAMAOBATMHDAC3HDAC4
SCHEMBL524603 0.82 GPR3 (0.50) ATMHDAC3HDAC4HDAC7HDAC8
SCHEMBL29950614 0.82 GPR3 (0.50) ATMHDAC3HDAC4HDAC7HDAC8
SCHEMBL23818652 0.77 MAPK1 (0.37) MAOAMAOBATMCYP2C9MEN1
SCHEMBL7535279 0.74 MAOA (0.52) MAOAMAOBATMHDAC3HDAC4
SCHEMBL28627118 0.73 MAOA (0.45) MAOAMAOBATMHDAC3HDAC4
SCHEMBL8516771 0.73 MAOA (0.50) MAOAMAOBATMHDAC3HDAC4
SCHEMBL29056534 0.72 MAOA (0.61) MAOAMAOBATMHDAC3HDAC4
SCHEMBL16835547 0.72 MAOA (0.61) MAOAMAOBATMHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102786508-A Spiro-fluorene-9,9-xanthene bipolar luminescent material, its preparation method and its application method UNIV NANJING POSTS & TELECOMM 2012-11-21 CN claimed
EP-0891344-A1 ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1999-01-20 EP claimed
WO-1997037983-A1 α1-ADRENERGIC RECEPTOR ANTAGONISTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1997-10-16 WO claimed
US-20210286266-A1 MATERIAL FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, AND COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 2021-09-16 US disclosed
CN-102786508-A Spiro-fluorene-9,9-xanthene bipolar luminescent material, its preparation method and its application method UNIV NANJING POSTS & TELECOMM 2012-11-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210286266-A1 MATERIAL FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, PATTERNING PROCESS, AND COMPOUND EPCAM, CDH1, DNMT3L MAOA 275/4885MAOB 424/4885ATM 1629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.