Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 5/20 | 0.66 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851703 | 0.86 | MRGPRX1 (0.52) | MRGPRX1ST14F2PRSS1PRSS2 | |
| SCHEMBL851435 | 0.84 | MRGPRX1 (0.82) | MRGPRX1ST14F2PRSS1PRSS2 | |
| SCHEMBL851855 | 0.82 | ST14 (0.73) | MRGPRX1ST14F2PRSS1PRSS2 | |
| SCHEMBL851411 | 0.79 | MRGPRX1 (0.51) | MRGPRX1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL851450 | 0.75 | SLC22A12 (0.54) | MRGPRX1CACNA1HCACNA1BKMT2AFFAR1 | |
| SCHEMBL3274521 | 0.73 | CACNA1H (0.53) | MRGPRX1CACNA1HCACNA1BTDP1HTT | |
| SCHEMBL5955235 | 0.73 | CYP2C9 (0.59) | MRGPRX1CYP1A2CYP2C9HTTLMNA | |
| SCHEMBL3275031 | 0.73 | MRGPRX1 (0.49) | MRGPRX1LMNAMAPTKMT2A | |
| SCHEMBL5955381 | 0.70 | STAT3 (0.60) | FFAR1FFAR4 | |
| SCHEMBL3050790 | 0.70 | PTPN1 (0.61) | MRGPRX1CACNA1HCACNA1BTDP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | MRGPRX1 202/4885ST14 216/4885F2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.