SCHEMBL8517700

SCHEMBL8517700

C[Si](C)([K])Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.43
KCNH2 Q12809 1/20 0.41
CALM1 P0DP23 1/20 0.41
SLC6A2 P23975 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
NR1H2 P55055 1/20 0.39
NR1H3 Q13133 1/20 0.39
TSHR P16473 3/20 0.39
ALDH1A1 P00352 3/20 0.39
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.38
IDO1 P14902 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.38
TRPA1 O75762 1/20 0.38
KDM4E B2RXH2 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3406066 0.79 TP53 (0.43) TP53CALM1NR1H2NR1H3TSHR
SCHEMBL1107767 0.78 TP53 (0.48) TP53CALM1SLC6A2TAAR1NR1H2
SCHEMBL16378246 0.78 TP53 (0.48) TP53CALM1SLC6A2TAAR1NR1H2
SCHEMBL231005 0.78 ESR1 (0.56) TP53CALM1NR1H2NR1H3TSHR
SCHEMBL8384621 0.75 TDP1 (0.48) TP53KCNH2TAAR1ALDH1A1LOXL2
SCHEMBL679387 0.74 TSHR (0.43) TP53CALM1TAAR1NR1H2NR1H3
SCHEMBL9224737 0.74 TP53 (0.43) TP53CALM1NR1H2NR1H3TSHR
SCHEMBL2098666 0.74 TP53 (0.43) TP53CALM1NR1H2NR1H3TSHR
SCHEMBL8381659 0.74 TP53 (0.43) TP53KCNH2CALM1NR1H2NR1H3
SCHEMBL122439 0.74 TP53 (0.43) TP53CALM1NR1H2NR1H3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630933-B1 A method of producing a semiconducting material NIPPON OIL CO LTD (JP) 1999-04-14 EP disclosed
US-5700400-A Method for producing a semiconducting material NIPPON OIL CO., LTD. (JP) 1997-12-23 US disclosed
EP-0551771-B1 Process for producing polysilanes NIPPON OIL CO LTD (JP) 1997-07-30 EP disclosed
US-5620531-A Photovoltaic element NIPPON OIL CO., LTD. (JP) 1997-04-15 US disclosed
EP-0717451-A2 Photovoltaic element NIPPON OIL CO., LTD. (JP) 1996-06-19 EP disclosed
EP-0630933-A2 A method of producing a semiconducting material NIPPON OIL CO. LTD. (JP) 1994-12-28 EP disclosed
US-5304622-A Process for producing polysilanes NIPPON OIL COMPANY, LTD. (JP) 1994-04-19 US disclosed
EP-0551771-A2 Process for producing polysilanes NIPPON OIL CO. LTD. (JP) 1993-07-21 EP disclosed